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CD20 and CD19 promote proliferation driven by the IgM-TLR9-L265P MyD88 complex.
Int Immunol
January 2025
Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo; Minato-ku, Tokyo 108-8639, Japan.
The cancer driver mutation L265P MyD88 is found in approximately 30 % of cases in the activated B cell-like subgroup of diffuse large B cell-like lymphoma (ABC DLBCL). L265P MyD88 forms a complex with TLR9 and IgM, referred to as the My-T-BCR complex, to drive proliferation. We here show that the B cell surface molecules CD19 and CD20 enhance proliferation mediated by the My-T-BCR complex.
View Article and Find Full Text PDFInvestigating the quality of European silver eels by quantifying contaminants and parasite infestation in a French Mediterranean lagoon complex.
Environ Sci Pollut Res Int
January 2025
Tour du Valat, Research Institute for the Conservation of Mediterranean Wetlands, Le Sambuc, Arles, France.
Coastal lagoons are diverse habitats with significant ecological gradients, which provide crucial ecosystem services but face threats from human activities such as invasive species and pollution. Among the species inhabiting the lagoons, the critically endangered European eel (Anguilla anguilla) is an emblematic species strongly impacted by contamination and parasitism. Several indicators were developed to assess the quality of eel at a large geographic scale.
View Article and Find Full Text PDFChallenges of in Poultry: Biological Insights, Economic Impact and Management Strategies.
Insects
January 2025
Centre for Agricultural Genomics and Biotechnology, University of Debrecen, H-4032 Debrecen, Hungary.
Bird mites are parasites that feed on both wild and domesticated bird species, causing severe degradation in avian welfare. The chicken mite, in particular, is a widespread ectoparasite in poultry, responsible for several challenges faced by the poultry industry, including poor animal health, which causes significant economic losses. This review, based on our current knowledge, aims to provide a comprehensive insight into the biology and distribution of these mites, as well as their impact on poultry health and production.
View Article and Find Full Text PDFMorphological and Molecular Identification of Obligatory Myiasis-Causing Species in Wild Cervids in Croatia.
Animals (Basel)
January 2025
Department of Bacteriology and Parasitology, Croatian Veterinary Institute, 10000 Zagreb, Croatia.
The infestation of ruminants by fly larvae of the Oestridae family can lead to nasopharyngeal or subcutaneous myiasis, which can harm animal welfare and productivity on sheep and cattle farms. The infestation of wild ruminants allows them to serve as reservoirs for subsequent transfer to domestic animals. The fly species most commonly responsible for myiasis have been well studied in many parts of the world, but less so in southeastern Europe.
View Article and Find Full Text PDFWild Boar Attacks on Hunting Dogs in Czechia: The Length of the Hunting Season Matters.
Animals (Basel)
January 2025
Department of Game Management and Wildlife Biology, Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague, 165 21 Praha, Czech Republic.
Hunting dogs are exposed to the risk of injury in driven hunts, an often-used method for managing growing wild boar numbers. This study investigated the impact of increased hunting pressure-both across the hunting season and within individual hunting events-on the risk of wild boar attacks on hunting dogs, i.e.
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