Our study describes a new development featuring iodine-catalyzed two consecutive oxidative cross-coupling reactions involving C(sp)-H of benzyl amines followed by intramolecular cyclization in water under air. Here, C-N coupling followed by C-C coupling occurs in a green environment to provide a variety of 5-pyrazino[2,3-]indoles within a short time period.
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| http://dx.doi.org/10.1039/d3cc01631e | DOI Listing |
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