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http://dx.doi.org/10.1038/s41396-023-01443-8 | DOI Listing |
Nat Microbiol
May 2024
Centre for Bacterial Resistance Biology, Imperial College London, London, UK.
Dormant prophages protect lysogenic cells by expressing diverse immune systems, which must avoid targeting their cognate prophages upon activation. Here we report that multiple Staphylococcus aureus prophages encode Tha (tail-activated, HEPN (higher eukaryotes and prokaryotes nucleotide-binding) domain-containing anti-phage system), a defence system activated by structural tail proteins of incoming phages. We demonstrate the function of two Tha systems, Tha-1 and Tha-2, activated by distinct tail proteins.
View Article and Find Full Text PDFISME J
July 2023
College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, 410082, PR China.
Virus Genes
April 2023
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, Shandong, China.
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