AI Article Synopsis
- This study investigates the role of pericytes in West syndrome, a type of epilepsy, by examining their relationship to the blood-brain barrier and neuroinflammation.
- It involved a comparison of serum levels of specific pericyte markers and cytokines between 18 pediatric patients with West syndrome and 9 healthy controls.
- Results showed increased levels of CD13 and decreased levels of PDGFRβ in West syndrome patients, suggesting that pericytes may play a role in the condition's development.
Article Abstract
Background: Pericytes play a role in the maintenance of the blood-brain barrier and neuroinflammation, attracting attention as to whether they are also involved in the pathogenesis of epilepsy.This study aimed to explore the relationship between West syndrome and pericytes.
Methods: Eighteen Japanese pediatric West syndrome patients and nine controls aged 2 years or younger were retrospectively enrolled in this study. We assessed theserumlevels of pericyte markers, serum PDGFRβ (platelet-derived growth factor receptorβ),CD13 (aminopeptidase N), and 27 cytokines in 17 pediatric patients with West syndrome and the control group.
Results: Patients with West syndrome exhibited significantly increased CD13 and decreased PDGFRβ levels, compared with controls but not serum cytokine levels. These values did not differ significantly between symptomatic and idiopathic West syndrome.
Conclusion: Pericytes might be implicated in the pathogenesis of West syndrome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.braindev.2023.05.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!