Ganoderma lucidum polysaccharide alleviates Cd toxicity in common carp (Cyprinus carpio): Neuropeptide, growth performance and lipid accumulation.

Cadmium (Cd) is the most common heavy metal and is easily detected in aquatic environments on a global scale. Common carp (Cyprinus carpio) is a common cultural species in aquaculture. This study aimed the polysaccharide from Ganoderma lucidum in ameliorating Cd-induced toxicity in common carp. The study included a blank control group (CK, without Cd and GPL) and LGPL group (2 g/kg LGPL + 0.5 mg/L Cd) and HGPL group (4 g/kg HGPL + 0.5 mg/L Cd). The fish were sampled at 2 and 4 weeks, and bioaccumulation, neurotransmitters, lipid accumulation, and growth performance were measured. Ganoderma lucidum polysaccharide administration can significant protect against Cd toxicity by reducing Cd bioaccumulation in tissues, regulating neurotransmitters, decreasing lipid accumulation, and enhancing growth performance. Our results suggested that administering Ganoderma lucidum polysaccharides can alleviate waterborne Cd toxicity in common carp.