Cureus
Faculty of Life Sciences and Medicine, King's College London, London, GBR.
Published: April 2023
Background Local anesthetic fascia iliaca blocks (FIB) are used for peri- and post-operative analgesia in hip fracture patients. The loss of resistance technique (LORT) and the suprainguinal approach (SIA) are two techniques commonly used. We present a pilot, first cadaveric study model that compares both techniques. Methods Methylene blue dye was injected as a local anesthetic substitute. This dye is easily visible. Both hips on each of the seven cadavers were injected with one of the two techniques used per side. Single-blinded randomization was conducted to determine the technique to be administered in each hip. Ten minutes after injection, the dissection of the femoral, obturator, and lateral femoral cutaneous nerves (LFCN) revealed the dye spread around these nerves. The SIA and the LORT were compared in their area of dye distribution using the Wilcoxon matched-pairs signed-rank test. The hips of a single cadaver were matched, since these received the injection via a different technique. Results The area of dye spread was greater in the SIA for five cadavers. Dye spread was greater following the LORT in two cadavers. However, the Wilcoxon matched-pairs signed-ranked test revealed no statistically significant difference in the area of dye spread following both techniques (p= 0.866). The SIA showed that the femoral, obturator, and LFCN were stained in six, three, and seven cadavers, respectively. The LORT resulted in five, two, and five of these nerves being stained, respectively. Conclusion This study found no statistically significant difference in terms of the area of dye spread between the SIA and the LORT. The number of nerves stained was greater following the SIA. This suggests that the SIA may lead to superior anesthetic outcomes. This conclusion is limited by the low sample size in this study. This work warrants the collection of more data through the same method to support or challenge our findings.
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http://dx.doi.org/10.7759/cureus.38243 | DOI Listing |
Anal Chem
January 2025
Laboratoire d'Innovation Thérapeutique, UMR7200 CNRS, Université de Strasbourg, Institut du Médicament de Strasbourg, 74 route du Rhin, Strasbourg F-67000, France.
The worldwide spread of antibiotic resistance is considered to be one of the major health threats to society. While developing new antibiotics is crucial, there is also a strong need for next-generation analytical methods for studying the physiological state of live bacteria in heterogeneous populations and their response to environmental stress. Here we report a single-cell high-throughput method to monitor changes in the bacterial cell envelope in response to stress based on ratiometric flow cytometry.
View Article and Find Full Text PDFAnal Chim Acta
February 2025
Department of Microbiology, The Medicine School of Hunan University of Chinese Medicine, Changsha, Hunan, 410208, People's Republic of China. Electronic address:
Background: Pathogenic bacteria are widespread in nature and can cause infections and various complications, thereby posing a severe risk to public health. Therefore, simple, rapid, sensitive, and cost-effective methods must be developed to detect pathogenic bacteria. Biosensors are prominent platforms for detecting pathogenic bacteria owing to their high sensitivity, specificity, repeatability, and stability.
View Article and Find Full Text PDFBiophys Chem
January 2025
La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia. Electronic address:
The rapid spread of antibiotic-resistant strains of bacteria has created an urgent need for new alternative antibiotic agents. Membrane disrupting antimicrobial peptides (AMPs): short amino acid sequences with bactericidal and fungicidal activity that kill pathogens by permeabilizing their plasma membrane may offer a solution for this global health crisis. Magainin 2 is an AMP secreted by the African clawed frog (Xenopus laevis) that is described as a toroidal pore former membrane disrupting AMP.
View Article and Find Full Text PDFBr J Anaesth
January 2025
Department of Anaesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Background: Spread of local anaesthetic solution in the paravertebral space after erector spinae plane block (ESPB) is variable. We evaluated whether paravertebral spread of local anaesthetic is affected by patient position after ESPB.
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Ann Med
December 2025
Catholic Institute for Applied Anatomy, Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Introduction: The clinical feasibility and applicability of surface landmarks for Baxter nerve entrapment to proximal and distal sites is unclear. This study provides anatomical guidelines for optimal transducer placement using two specific landmarks, the most inferior tip of the medial malleolus (A) and the most protruding posterior tip of the calcaneus (B), to enhance the diagnostic and therapeutic injection efficacy for proximal and distal entrapment sites.
Materials And Methods: Eighty-six feet from 45 fresh cadavers (25 male and 20 female) were dissected to determine Baxter's nerve (BN) localization.
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