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| http://dx.doi.org/10.4103/sja.sja_568_22 | DOI Listing |
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Comparison of hemodynamic responses to nasal intubation in cancer patients receiving opioid-free general anesthesia versus standard regimen.
J Anaesthesiol Clin Pharmacol
November 2024
Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Background And Aims: Nasotracheal intubation evokes greater hemodynamic responses than oral intubation. We compared the heart rate (HR) and mean arterial pressure (MAP) responses following nasal intubation during opioid-free anesthesia (OFA) using intravenous lignocaine versus standard regimen using morphine in cancer patients undergoing tumor resection.
Material And Methods: This randomized, double-blinded study was conducted in 84 adults.
The Effects of Opioid-Free Anesthesia with Dexmedetomidine and Esketamine on Postoperative Anesthetic-Related Complications for Hip Surgery in the Elderly.
Int J Gen Med
December 2024
Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
Purpose: The routine perioperative use of opioids has recently been questioned due to opioid-related side effects, which can be potentially harmful in geriatric patients. This study aimed to evaluate the effects of opioid-free anesthesia in geriatric patients undergoing hip surgery.
Patients And Methods: A total of 121 patients, aged 60 years or older, undergoing elective hip surgery were randomized to receive either opioid-free anesthesia with dexmedetomidine and esketamine (OFA group) or balanced anesthesia with opioids (CON group).
Reduction of postoperative pain and opioid consumption by VVZ-149, first-in-class analgesic molecule: A confirmatory phase 3 trial of laparoscopic colectomy.
J Clin Anesth
December 2024
Department of Anesthesiology and Pain Medicine, Seoul National University, College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:
Study Objective: VVZ-149 is a small molecule that inhibits the glycine transporter type 2 and the serotonin receptor 5-hydroxytryptamine 2 A. In this Phase 3 study, we investigated the efficacy and safety of VVZ-149 as a single-use injectable analgesic for treating moderate to severe postoperative pain after laparoscopic colectomy.
Design: Randomized, parallel group, double-blind, Phase 3 clinical trial (Trial no.
Impact of Dexmedetomidine-Based Opioid-Sparing Anesthesia on Opioid Use After Minimally Invasive Repair of Pectus Excavatum: A Prospective Randomized Controlled Trial.
J Clin Med
November 2024
Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Article Synopsis
- Opioid-sparing anesthesia (OSA) using dexmedetomidine reduces postoperative pain and opioid consumption compared to traditional opioid-based anesthesia (OBA) in patients undergoing pectus excavatum repair.
- The study involved 84 patients, showing that those in the OSA group required significantly less morphine-equivalent medication and reported lower pain scores in the first 48 hours after surgery.
- Recovery times and overall stability during the procedure were similar between the two groups, indicating that OSA is a safe and effective alternative to OBA.
Opioid-free anaesthesia and postoperative quality of recovery: a systematic review and meta-analysis with trial sequential analysis.
Anaesth Crit Care Pain Med
December 2024
Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; The Research Units of West China (2018RU012)-Chinese Academy of Medical Sciences, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:
Article Synopsis
- The study evaluates the effectiveness of opioid-free anesthesia (OFA) compared to opioid-based anesthesia (OBA) on the quality of recovery (QoR) for adult patients post-surgery.
- The analysis of 15 studies indicated OFA significantly enhances overall QoR and specifically improves physical comfort and pain management at 24 hours after surgery.
- Despite these findings, there is moderate-to-low evidence, and the variances in results need further research to confirm the reliability of OFA in different patient populations.
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