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Pharmacokinetics of 14C-ambazone in rats.
Pharmazie
March 1988
Academy of Sciences of the GDR, Central Institute of Microbiology and Experimental Therapy, Jena.
In rats, the pharmacokinetics of 14C-ambazone after i.v. and oral administration was studied.
View Article and Find Full Text PDFDistribution of 14C-ambazone in normal and leukemia P 388-bearing mice.
Arch Geschwulstforsch
October 1988
Central Institute of Microbiology and Experimental Therapy, Academy of Sciences of the GDR, Jena.
There is some evidence in the literature that the pharmacokinetics of anticancer agents can be influenced by the presence of a tumor. Therefore several authors recommend pharmacokinetic studies of such drugs to be performed also in tumor-bearing animals (2, 5, 7). The aim of the present study was to evaluate the influence of different stages and routes of inoculation of leukemia P 388 in B6D2F1-hybrid mice on the tissue distribution of ambazone, a new potential antineoplastic drug.
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