AI Article Synopsis
- Nephrotic syndrome (NS) is a condition that internists need to identify, caused by various factors like infections, autoimmune issues, and cancer.
- The syndrome is characterized by symptoms such as proteinuria (excess protein in urine), edema (swelling), and hypoalbuminemia (low albumin levels).
- It results from increased glomerular permeability, leading to significant health complications, including kidney inflammation and problems with fluid balance and immunity.
Article Abstract
Nephrotic syndrome (NS) is a key clinical entity for the internist to recognize and understand. A wide range of infectious, metabolic, malignant, and autoimmune processes drive nephrosis, leading to a syndrome defined by proteinuria, edema, and hypoalbuminemia. NS occurs due to increased permeability to proteins at the level of the glomerulus, which allows for passage of albumin and other proteins into the urine. Proteinuria leads to a cascade of clinical complications characterized by fluid accumulation, kidney inflammation, and dysregulation of coagulation and immunity. In this article, the authors review the clinically important etiologies of NS that should inform an initial clinical evaluation.
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| http://dx.doi.org/10.1016/j.mcna.2023.03.006 | DOI Listing |
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