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Mid-term outcomes of atrioventricular valve repair in functional single ventricle patients.
Front Cardiovasc Med
December 2024
Heart Center, The First Hospital of Tsinghua University, Beijing, China.
Background: Surgical treatment of functional single ventricle combined with atrioventricular valve regurgitation remains a clinical challenge. The outcomes of atrioventricular valve repair in patients with single ventricle are limited.
Methods: A retrospective study was conducted of all 28 patients with functional single ventricle treated with single-ventricle palliation who underwent atrioventricular valve operation at the First Hospital of Tsinghua University between April 2007 and October 2022.
Evaluation of diagnostic criteria for mild-to-advanced stages of Fontan-associated liver disease: A nationwide epidemiological survey in Japan.
Hepatol Res
November 2024
The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, Ichikawa, Japan.
Aim: Fontan-associated liver disease (FALD) is a complication after Fontan surgery, and a common cause of liver tumors and cirrhosis. However, no diagnostic criteria for FALD have been established, leading to an underestimation of its prevalence.
Methods: We conducted a national survey to elucidate the characteristics of FALD by collecting data from high-volume centers managing patients who had undergone the Fontan surgery in Japan.
Management of Tricuspid Atresia With Normally Related Great Arteries and Left-Sided Obstruction.
World J Pediatr Congenit Heart Surg
November 2024
Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Article Synopsis
- Tricuspid atresia (TA) is a heart condition affecting infants and is the second most common type of functionally univentricular heart, with rare cases of left ventricular outflow tract obstruction (LVOTO) in patients who have normally related great arteries.
- A study involving 445 patients with Type I TA showed that 3% of infants needed interventions for LVOTO, and most of those who underwent surgical procedures had promising outcomes.
- The long-term survival rate for these infants was estimated at 79% over 20 years, indicating that timely surgical management can lead to successful interventions and good heart function later in life.
Systolic Function in the Fontan Circulation Is Exercise, but Not Preload, Recruitable.
J Am Soc Echocardiogr
November 2024
Department of Paediatric Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Background: Fontan circulatory failure with impaired systolic function is well documented; however, its mechanisms are not fully understood. The aim of this study was to explore myocardial functional reserve in adolescent patients with Fontan circulation in response to exercise or acute preload increase.
Methods: The study included 32 patients (median age, 16.
Investigation of a chronic single-stage sheep Fontan model.
JTCVS Open
October 2024
Center for Regenerative Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Article Synopsis
- This study aimed to analyze the hemodynamics of a new animal model of Fontan physiology, which is important for understanding poor long-term outcomes in Fontan patients.
- Researchers created a single-stage Fontan model in juvenile sheep and conducted detailed hemodynamic assessments.
- Results showed that only a fraction of the sheep survived, with survival rates improving over time due to a learning curve; the study identified key hemodynamic characteristics but noted anatomical differences that affected the model's accuracy, suggesting surgical modifications could enhance future studies.
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