NHSN total IV antimicrobial start rates for patients on hemodialysis decreased from 2016 to 2020, but rates unsupported by NHSN surveillance documentation did not. There were 80% of reporting hemodialysis facilities that had ≥1 unsupported IV antimicrobial start, and the fraction of facilities with unsupported starts increased yearly. Accurate reporting and timely review of antimicrobial data is critical to understanding prescribing trends and practices in hemodialysis facilities.
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http://dx.doi.org/10.34067/KID.0000000000000167 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Institute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen 52074, Germany.
Postnatal establishment of enteric metabolic, host-microbial and immune homeostasis is the result of precisely timed and tightly regulated developmental and adaptive processes. Here, we show that infection with the invasive enteropathogen Typhimurium results in accelerated maturation of the neonatal epithelium with premature appearance of antimicrobial, metabolic, developmental, and regenerative features of the adult tissue. Using conditional Myd88-deficient mice, we identify the critical contribution of immune cell-derived mediators.
View Article and Find Full Text PDFJ Contemp Dent Pract
September 2024
Department of Academic, Faculty of Dentistry, Universidad Nacional Federico Villarreal, Lima, Peru, ORCID: https://orcid.org/0000-0002-0594-5834.
Objective: To evaluate the shear strength of adhesives based on the type of solvent (ethanol and acetone), aged and light-cured using light-emitting diode (LED) units with different wavelengths. Polywave and monowave LED units were employed for this study.
Materials And Methods: Ninety bovine tooth samples were analyzed using OptiBond Universal adhesive (acetone) and single bond universal adhesive (ethanol).
Cureus
December 2024
Department of Ophthalmology, Hospital University Kebangsaan Malaysia, Kuala Lumpur, MYS.
We report a rare case of a missed intracavernous internal carotid artery dissecting aneurysm occurring as a complication of the base of skull fracture with severe brain injury causing acute cavernous sinus syndrome with permanent vision loss. A 31-year-old Myanmar lady had an alleged motor vehicle accident and suffered severe traumatic brain injury with multiple intracranial bleeds, multiple facial bone and base of skull fractures, and limb fractures. At one week post-trauma, she had severe right eye proptosis with vision loss, ophthalmoplegia, chemosis, and high intraocular pressure.
View Article and Find Full Text PDFBMC Health Serv Res
January 2025
Faculty of Communication, Culture and Society, Università Della Svizzera Italiana, Lugano, Switzerland.
Background: Delayed prescription is a strategy used in various countries to reduce antibiotic overuse and contend the effects of antibiotic resistance; however this practice is not yet used in Switzerland. The present qualitative study was thus conducted to investigate Swiss patients' attitudes towards the possible implementation of delayed prescription.
Method: Five focus groups with the general population based on a fixed script of questions to elicit opinions on delayed prescription.
Trials
January 2025
Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea.
Background: Prophylactic parenteral administration of antibiotics is strongly recommended to prevent surgical site infection (SSI). Cefoxitin is mainly administered intravenously in colorectal surgery. The current standard method for administering prophylactic antibiotics in adults is to administer a fixed dose quickly before skin incision.
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