A method for chemoselective reduction of 2-pyridyl ketones and related -heteroaryl compounds catalyzed by cobalt stearate using DMF as a hydride source is developed. The ketone substrate is activated by chelation with cobalt, which makes the present method highly chemoselective. A possible reaction mechanism is proposed on the basis of control experiments.
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| http://dx.doi.org/10.1021/acs.joc.3c00283 | DOI Listing |
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