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The Contribution of Macrophage Plasticity to Inflammatory Arthritis and Their Potential as Therapeutic Targets.
Cells
September 2024
School of Biotechnology, Dublin City University, D09 V209 Dublin, Ireland.
Article Synopsis
- Inflammatory arthritis is a chronic autoimmune disease causing joint inflammation, loss of function, and significant comorbidities, with only 20% of patients achieving drug-free remission for over two years.
- Macrophages are crucial in inflammation; M1 macrophages promote inflammation and joint degradation, while M2 macrophages aid in healing and resolving inflammation, with various subtypes of M2 macrophages identified.
- Current treatments do not specifically target macrophages, but research is focused on repolarizing pro-inflammatory M1 macrophages to anti-inflammatory M2 types as a potential therapeutic strategy, highlighting the need to understand macrophage plasticity for effective new treatments.
Ten quick tips for electrocardiogram (ECG) signal processing.
PeerJ Comput Sci
September 2024
STADIUS Center for Dynamical Systems Signal Processing and Data Analytics, Katholieke Universiteit Leuven, Leuven, Belgium.
The electrocardiogram (ECG) is a powerful tool to measure the electrical activity of the heart, and the analysis of its data can be useful to assess the patient's health. In particular, the computational analysis of electrocardiogram data, also called ECG signal processing, can reveal specific patterns or heart cycle trends which otherwise would be unnoticeable by medical experts. When performing ECG signal processing, however, it is easy to make mistakes and generate inflated, overoptimistic, or misleading results, which can lead to wrong diagnoses or prognoses and, in turn, could even contribute to bad medical decisions, damaging the health of the patient.
View Article and Find Full Text PDFTen quick tips for clinical electroencephalographic (EEG) data acquisition and signal processing.
PeerJ Comput Sci
September 2024
Dipartimento di Informatica Sistemistica e Comunicazione, Università di Milano-Bicocca, Milan, Milan, Italy.
Electroencephalography (EEG) is a medical engineering technique aimed at recording the electric activity of the human brain. Brain signals derived from an EEG device can be processed and analyzed through computers by using digital signal processing, computational statistics, and machine learning techniques, that can lead to scientifically-relevant results and outcomes about how the brain works. In the last decades, the spread of EEG devices and the higher availability of EEG data, of computational resources, and of software packages for electroencephalography analysis has made EEG signal processing easier and faster to perform for any researcher worldwide.
View Article and Find Full Text PDF(Why) did it turn wrong? Wholeness or totality of the Internet.
Am J Psychoanal
June 2024
Department of Psychiatry, Lithuanian University of Health Sciences (LUHS), Eiveniu str. 2, 50161, Kaunas, LT, Lithuania.
The Internet was created as a space and a structure to share knowledge, information, and opinions for the sake of science and progression of humanity. Today, the Internet is co-created and modified by its users networking from all over the world. It is a representation of humankind, a social structure reactive to local and global societal processes.
View Article and Find Full Text PDFIn 1971, two years before Roe v. Wade affirmed federal protection for abortion, Judith Jarvis Thomson attempted to demonstrate the wrongs of forced gestation through analogy: you awake to find that the world's most esteemed violinist is wholly, physically dependent on you for life support. Here, the authors suggest that Thomson's intuition, that there is a relevant similarity between providing living kidney support and forced gestation, is realized in the contemporary practice of living organ donation.
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