Manipulation of an electron by photoirradiation in the electron-catalyzed cross-coupling reaction.

Sci Adv

Department of Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, Higashihiroshima, Hiroshima 739-8526, Japan.

Published: June 2023

An electron has recently been shown to catalyze the cross-coupling reaction of organometallic compounds with aryl halides. In terms of green and sustainable chemistry, the electron catalysis is much more desirable than the inevitably used transition metal catalysis but a high temperature of more than 100°C is required to achieve it. Here, we disclose that visible light photoirradiation accelerates the electron-catalyzed reaction of arylzinc reagents with aryl halides with the aid of a photoredox catalysis. Photoexcitation of a photoredox catalyst and an anion radical intermediate respectively affects the supply and transfer of the electron catalyst, promoting the cross-coupling reaction to proceed at room temperature. The supply of the electron catalyst by the photoredox catalysis makes the scope of aryl halides wider.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413655PMC
http://dx.doi.org/10.1126/sciadv.adh3544DOI Listing

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