The original article was published in Folia Biologica (Praha) Volume 68, No. 3 (2022), 112-124.
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Chondrosarcoma with Target-Like Chondrocytes: Update on Molecular Profiling and Specific Morphological Features.
Folia Biol (Praha)
January 2023
Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
This is the first histological and molecular analysis of two chondrosarcomas with target-like chondrocytes that were compared with a group of conventional chondrosarcomas and enchondromas. The unique histological feature of target-like chondrocytes is the presence of unusual hypertrophic eosinophilic APAS-positive perichondrocytic rings (baskets). In the sections stained with Safranin O/Fast green, the outer part of the ring was blue and the material in the lacunar space stained orange, similarly to intercellular regions.
View Article and Find Full Text PDFChondrosarcoma with Target-Like Chondrocytes: Update on Molecular Profiling and Specific Morphological Features.
Folia Biol (Praha)
June 2023
Department of Otorhinolaryngology, Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
The original article was published in Folia Biologica (Praha) Volume 68, No. 3 (2022), 112-124.
View Article and Find Full Text PDFTarget-like chondrocytes with thick perichondrocytic rings in cartilage-forming tumours. Preliminary report.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
June 2021
Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Background: Here we present our experience with the occurrence of neoplastic chondrocytes with target-like appearance surrounded with unusual hypertrophic thick eosinophilic perichondrocytic rings (baskets), sometimes containing two or several layers.
Methods And Results: Pericellular rings (baskets) were positive in APAS and Masson's staining method and showed immunoreactivity with antibody against type IV collagen. Such single cells or small groups of such cells were observed rarely in 3 osteochondromas, 2 skeletal chondromas, 2 extraskeletal chondromas and 2 skeletal and 1 laryngeal chondrosarcomas.
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