Atrial septal defect (ASD) is a common congenital anomaly that increases the risk of heart failure as well as strokes which can lead to cognitive impairment. The risk of stroke is higher when pulmonary hypertension develops and there is reversal of shunt. Stroke in ASD may be due to paradoxical emboli from the right heart or a left ventricular thrombus which develops as a result of atrial fibrillation, a common arrhythmia in ASD. We present a case of a 32-year-old Ghanaian man with history of ASD who presented with progressive memory loss with magnetic resonance imaging scan of the brain showing multiple infarcts, microvascular disease, and cerebral atrophy.
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http://dx.doi.org/10.1177/11795476231176713 | DOI Listing |
Methods Cell Biol
January 2025
Federal University of Santa Maria, Center for Natural and Exact Sciences, Department of Biochemistry and Molecular Biology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Camobi, Santa Maria, RS, Brazil.
Alzheimer's disease (AD) is the leading cause of dementia in the elderly, clinically characterized by memory loss, cognitive decline, and behavioral disturbances. Its pathogenesis is not fully comprehended but involves intracellular depositions of amyloid beta peptide (Aβ) and neurofibrillary tangles of hyperphosphorylated tau. Currently, pharmacological interventions solely slow the progression of symptoms.
View Article and Find Full Text PDFLancet Neurol
February 2025
Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada; Department of Cognitive Neurology, St Joseph's Health Care London, London, ON, Canada. Electronic address:
Background: No treatments exist for apathy in people with frontotemporal dementia. Previously, in a randomised double-blind, placebo-controlled, dose-finding study, intranasal oxytocin administration in people with frontotemporal dementia improved apathy ratings on the Neuropsychiatric Inventory over 1 week and, in a randomised, double-blind, placebo-controlled, crossover study, a single dose of 72 IU oxytocin increased blood-oxygen-level-dependent signal in limbic brain regions. We aimed to determine whether longer treatment with oxytocin improves apathy in people with frontotemporal dementia.
View Article and Find Full Text PDFNutrients
January 2025
Neuroepidemiology Department, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, Cyprus.
Background/objectives: Dementia is not a single disease but an umbrella term that encompasses a range of symptoms, such as memory loss and cognitive impairments, which are severe enough to disrupt daily life. One of the most common forms of dementia is Alzheimer's Disease (AD), a complex neurodegenerative condition influenced by both genetic and environmental factors. Recent research has highlighted diet as a potential modifiable risk factor for AD.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Centre for Automation and Robotics (CAR UPM-CSIC), Escuela Técnica Superior de Ingeniería y Diseño Industrial (ETSIDI), Universidad Politécnica de Madrid, Ronda de Valencia 3, 28012 Madrid, Spain.
Analysis of the human gait represents a fundamental area of investigation within the broader domains of biomechanics, clinical research, and numerous other interdisciplinary fields. The progression of visual sensor technology and machine learning algorithms has enabled substantial developments in the creation of human gait analysis systems. This paper presents a comprehensive review of the advancements and recent findings in the field of vision-based human gait analysis systems over the past five years, with a special emphasis on the role of vision sensors, machine learning algorithms, and technological innovations.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Psychology, Università degli Studi della Campania "L. Vanvitelli", 81100 Caserta, Italy.
Mental representation of spatial information relies on egocentric (body-based) and allocentric (environment-based) frames of reference. Research showed that spatial memory deteriorates as Alzheimer's disease (AD) progresses and that allocentric spatial memory is among the earliest impaired areas. Most studies have been conducted in static situations despite the dynamic nature of real-world spatial processing.
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