AI Article Synopsis
- Patients in hemorrhagic shock can face a risk of enterogenic sepsis due to damage to the intestinal barrier, increasing the chance of bacteria and toxins entering the bloodstream after ischemic injury.
- A case involving a 56-year-old man who experienced severe hemorrhage during a liver surgery highlights the complex nature of this condition; despite reinforcements, his condition didn't improve until he received anti-infective treatment and hormone support.
- It’s crucial for healthcare professionals to be aware of potential enterogenic sepsis in such situations to ensure prompt recognition and effective treatment.
Article Abstract
Background: Patients with hemorrhagic shock may develop emerging enterogenic sepsis due to damage to the intestinal mucosal barrier and translocation of intestinal bacteria and endotoxins caused by ischemic injury. Because of the dual effects of anesthesia state and hemorrhagic shock, perioperative emerging enterogenic sepsis is even more rare and insidious.
Case Presentation: We reported a case of 56-year-old man who underwent right hepatectomy for intrahepatic bile duct stones. Severe hemorrhage occurred during the procedure and the hemodynamics neither improved nor worsened after rehydration therapy and vasoactive drug administration. Based on the patient's history and clinical presentation, a possible enterogenic sepsis was considered. After anti-infective treatment and hormone supplementation, the patient's circulation improved significantly and he had an uneventful recovery.
Conclusion: The possibility of emerging enterogenic sepsis in hemorrhagic shock must always be taken into consideration. Familiarity with the risk factors and pathophysiological alterations of enterogenic sepsis is a prerequisite for early recognition and sound clinical decision making.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228049 | PMC |
| http://dx.doi.org/10.1186/s12871-023-02108-x | DOI Listing |
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Article Synopsis
- Patients in hemorrhagic shock can face a risk of enterogenic sepsis due to damage to the intestinal barrier, increasing the chance of bacteria and toxins entering the bloodstream after ischemic injury.
- A case involving a 56-year-old man who experienced severe hemorrhage during a liver surgery highlights the complex nature of this condition; despite reinforcements, his condition didn't improve until he received anti-infective treatment and hormone support.
- It’s crucial for healthcare professionals to be aware of potential enterogenic sepsis in such situations to ensure prompt recognition and effective treatment.
Gut microbe-derived milnacipran enhances tolerance to gut ischemia/reperfusion injury.
Cell Rep Med
March 2023
Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address:
There are significant differences in the susceptibility of populations to intestinal ischemia/reperfusion (I/R), but the underlying mechanisms remain elusive. Here, we show that mice exhibit significant differences in susceptibility to I/R-induced enterogenic sepsis. Notably, the milnacipran (MC) content in the enterogenic-sepsis-tolerant mice is significantly higher.
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