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α-Stereoselective 3-Deoxy-d--oct-2-ulosonoic Acid (Kdo) -Glycosylation with a -Toluenethioglycoside Donor by the (-Tol)SO/TfO Preactivation Strategy. | LitMetric

AI Article Synopsis

  • A new method was developed to efficiently create α-Kdo glycosides using a specific preactivation strategy involving peracetylated Kdo thioglycoside as a donor.
  • The optimized conditions allowed the successful synthesis of various α-Kdo products, including different linkage types, all achieving high yields.
  • The study also led to the first successful construction of aromatic α-Kdo glycosides, with theoretical and experimental results suggesting an S2-like mechanism underlying the process.

Article Abstract

A convenient and efficient approach was developed to synthesize α-Kdo -glycosides based on the TfO/(-Tol)SO preactivation strategy using peracetylated Kdo thioglycoside as a donor. Under the optimized reaction conditions, several -glycoside products, including α-(2 → 1)-, α-(2 → 2)-, α-(2 → 3)-, and α-(2 → 6)-Kdo products, were stereoselectively synthesized in high yields. Remarkably, a series of aromatic α-Kdo -glycosides were first and successfully constructed in high yields. An S2-like mechanism was revealed by DFT calculations and experimental results.

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Source
http://dx.doi.org/10.1021/acs.orglett.3c01430DOI Listing

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