Synthesis of 2-(6-substituted quinolin-4-yl)-1-alkoxypropan-2-ol as potential antimycobacterial agents.

Unlabelled: Resistance to antibiotic drugs has directed global health security to a life-threatening situation due to mycobacterial infections. In search of a new potent antimycobacterial, a series of (±) 2-(6-substituted quinolin-4-yl)-1-alkoxypropan-2-ol () have been synthesized. The structures of the newly synthesized derivatives were characterized by spectrometric analysis. Derivatives were evaluated for antitubercular activity against H37Rv (ATCC 25177), antibacterial activity against (NCIM2388), (NCIM 2065), (NCIM2063) (NCIM 2178) and antifungal activity against (NCIM 3100), (ATCC 504). Thirteen 2-(6-substituted quinolin-4-yl)-1-alkoxypropan-2-ol ( derivatives reported moderate to good antitubercular activity against H37Rv with MIC 9.2-106.4 μM. Compounds and showed comparable activity with respect to the standard drug pyrazinamide. The active compounds screened for cytotoxicity activity against L929 mouse fibroblast cells showed no significant cytotoxic activity. Compounds , , , , , and displayed good activity against . Compounds and showed good activity against and , respectively. The potential antimycobacterial activities imposed that the 2-(6-substituted quinolin-4-yl)-1-alkoxypropan-2-ol derivatives could lead to compounds that could treat tuberculosis.

Supplementary Information: The online version contains supplementary material available at 10.1007/s11696-023-02741-3.