Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214518 | PMC |
| http://dx.doi.org/10.1021/acscentsci.3c00548 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Self-Optimizing Flow Reactors Get a Boost by Multitasking.
ACS Cent Sci
May 2023
Center for Continuous Flow Synthesis and Processing (CC FLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, Graz 8010, Austria.
Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self-Optimizing Flow Chemistry Platform.
Chemistry
August 2022
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
The implementation of self-optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self-optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C-C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization.
View Article and Find Full Text PDFNetwork science characteristics of brain-derived neuronal cultures deciphered from quantitative phase imaging data.
Sci Rep
September 2020
Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, 90007, USA.
Understanding the mechanisms by which neurons create or suppress connections to enable communication in brain-derived neuronal cultures can inform how learning, cognition and creative behavior emerge. While prior studies have shown that neuronal cultures possess self-organizing criticality properties, we further demonstrate that in vitro brain-derived neuronal cultures exhibit a self-optimization phenomenon. More precisely, we analyze the multiscale neural growth data obtained from label-free quantitative microscopic imaging experiments and reconstruct the in vitro neuronal culture networks (microscale) and neuronal culture cluster networks (mesoscale).
View Article and Find Full Text PDFSelf-optimizing parallel millifluidic reactor for scaling nanoparticle synthesis.
Chem Commun (Camb)
April 2020
Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, 925 Bloom Walk, Los Angeles, California 90089-1211, USA.
We developed a 16-channel millifluidic reactor that uses a multiphase gas-liquid flow to continuously produce colloidal CsPbBr quantum dots with a throughtput of ∼1 L h. The optical properties of the product were monitored, and the reaction conditions were optimized in real time based on the in situ photoluminescence characteristics of the quantum dots.
View Article and Find Full Text PDFAutomated Polymer Synthesis Platform for Integrated Conversion Targeting Based on Inline Benchtop NMR.
ACS Macro Lett
November 2019
Polymer Reaction Design Group, School of Chemistry, Monash University, 19 Rainforest Walk, Clayton, Victoria 3800, Australia.
An automated polymer synthesis platform based on an inline low-field nuclear magnetic resonance spectrometer is developed. Flow chemistry and automated inline analyses are an excellent combination for automated kinetic screening and for self-optimizing reactions with programmable conversion targeting. By monitoring monomer conversion over a continuous range of reactor residence times, the platform is able to construct kinetic profiles of polymerizations in an accurate and efficient way.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!