Rheumatic heart disease (RHD) is a widespread illness in developing countries. RHD causes 99% of mitral stenoses in adults and 25% of aortic regurgitation. However, it only causes 10% of stenoses of the tricuspid valve, and is almost always associated with left-side valvular lesions. Isolated right-side valves are rarely affected, but may result in severe rheumatic pulmonary regurgitation. Herein, we present a case of rheumatic right-sided valve disease with severe pulmonary valve contracture and regurgitation in a symptomatic patient, successfully managed by surgical valvular reconstruction with a tailored bileaflet bovine pericardial patch. The options for surgical approach are also discussed. To our knowledge, the presented rheumatic right-sided valve disease with severe pulmonary regurgitation is the first to be reported in the literature.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213930PMC
http://dx.doi.org/10.3389/fcvm.2023.1129529DOI Listing

Publication Analysis

Top Keywords

rheumatic right-sided
12
right-sided valve
12
valve disease
12
disease severe
12
severe pulmonary
12
pulmonary regurgitation
12
surgical valvular
8
pulmonary
5
rheumatic
5
valve
5

Similar Publications

Daptomycin alleviates collagen-induced arthritis via suppressing inflammatory cytokines and NF-κB pathway.

Int Immunopharmacol

January 2025

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, No.17, 3rd Section of People's South Road, Chengdu, 610041, PR China. Electronic address:

Article Synopsis
  • Rheumatoid arthritis (RA) is a chronic autoimmune disease influenced by factors like bacterial infection and immune inflammation.
  • Daptomycin (DAP), known for its antibacterial properties, is being studied for its potential anti-inflammatory effects on RA.
  • Research shows that DAP reduces inflammation in RA models by lowering key inflammatory markers and signaling pathways, suggesting its potential for broader clinical use beyond just treating infections.
View Article and Find Full Text PDF

Background/aim: Connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) is a severe complication characterized by elevated pulmonary artery pressure, which can lead to right heart failure and death, if untreated. Standard treatments often fail to adequately manage symptoms, highlighting the need for novel therapeutic approaches. This study investigated the efficacy of molecular hydrogen (H) therapy in a patient with CTD-PAH.

View Article and Find Full Text PDF

Clinical outcome of patients with rheumatic tricuspid valve disease: matched cohort study.

Int J Cardiovasc Imaging

September 2024

Hospital das Clínicas and Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Professor Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, 30130-100, MG, Brazil.

Rheumatic heart disease (RHD) is still a major health problem, especially in low- to mid-income countries, leading premature deaths owing to valvular disease. Although left-sided valvular involvement is most commonly seen in RHD, the tricuspid valve can also be affected. However, there is a lack of information about the prognostic value of primary tricuspid valve (TV) disease in RHD.

View Article and Find Full Text PDF

Transcatheter tricuspid valve intervention (TTVI) has emerged as a promising alternative for patients with severe tricuspid regurgitation who are deemed high-risk for surgery. With advancements in device design and delivery systems, TTVI has shown promising outcomes in reducing tricuspid regurgitation severity and improving symptoms in selected patients. Paravalvular leaks (PVLs) are one of the most common complications faced, which can significantly contribute to patients' morbidity and mortality.

View Article and Find Full Text PDF

Background: Granulomatosis with polyangiitis (GPA) is one of the most prevalent forms of the antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. GPA is characterized histologically by necrotizing granulomatous inflammation in addition to vasculitis. The diagnosis of GPA depends on clinical presentation, serological evidence of a positive ANCA, and/or histological evidence of necrotizing vasculitis or granulomatous destructive parenchymal inflammation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!