AI Article Synopsis
- Previous studies on smoking and Alzheimer's disease (AD) have produced conflicting results, prompting this study to utilize Mendelian randomization (MR) for better clarity.
- Researchers analyzed genetic variations linked to smoking (cigarettes per day) in a Chinese cohort of 1,000 AD cases and 500 controls, as well as a Japanese cohort of nearly 8,000 participants.
- The findings indicated that higher genetic predisposition to smoking did not show a causal link to AD risk in either population, suggesting no significant association between smoking and Alzheimer's disease.
Article Abstract
Background: Previous epidemiological studies have reported controversial results on the relationship between smoking and Alzheimer's disease (AD). Therefore, we sought to assess the association using Mendelian randomization (MR) analysis.
Methods: We used single nucleotide polymorphisms (SNPs) associated with smoking quantity (cigarettes per day, CPD) from genome-wide association studies (GWAS) of Japanese population as instrumental variables, then we performed two-sample MR analysis to investigate the association between smoking and AD in a Chinese cohort (1,000 AD cases and 500 controls) and a Japanese cohort (3,962 AD cases and 4,074 controls), respectively.
Results: Genetically higher smoking quantity showed no statistical causal association with AD risk (the inverse variance weighted (IVW) estimate in the Chinese cohort: odds ratio (OR) = 0.510, 95% confidence interval (CI) = 0.149-1.744, = 0.284; IVW estimate in the Japanese cohort: OR = 1.170, 95% confidence interval CI = 0.790-1.734, = 0.434).
Conclusion: This MR study, for the first time in Chinese and Japanese populations, found no significant association between smoking and AD.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213305 | PMC |
| http://dx.doi.org/10.3389/fnagi.2023.1157051 | DOI Listing |
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