AI Article Synopsis
- Endometrial cancer is the most common gynecological cancer in the U.S., but its prevalence in transgender men remains largely unknown, with only four documented cases.
- A 36-year-old transgender man, assigned female at birth, was diagnosed with early-stage endometrial cancer after experiencing vaginal bleeding, despite being on testosterone therapy for five years.
- This case highlights that transgender men can develop endometrial carcinoma and emphasizes the importance of routine gynecological care for this population.
Article Abstract
Objective: Endometrial cancer is the most common gynecological malignancy in the United States. Despite the high prevalence amongst cisgender females the prevalence of this gynecological malignancy in transgender men has not been clearly identified. To date, only four reported cases have been described in the literature.
Case: A 36-year-old nulliparous assigned female at birth, transgender premenopausal male underwent a laparoscopic total hysterectomy, bilateral salpingo-oophorectomy, sentinel lymph node mapping and omental biopsy after having an endometrial biopsy that demonstrated well differential endometroid adenocarcinoma. He had been on testosterone therapy for at least five years prior to presenting to his gynecologist with the chief complaint of vaginal bleeding. Final pathology showed FIGO Stage 1A endometroid endometrial carcinoma.
Conclusion: This case report adds to the body of literature demonstrating that transgender men can develop endometrial carcinoma while on exogenous testosterone therapy. In addition, this report illustrates the importance of routine gynecological care in the transgender patient population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209109 | PMC |
| http://dx.doi.org/10.1016/j.gore.2023.101199 | DOI Listing |
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