This Perspective highlights the work of Dr. Daniela Novick in the field of cytokine biology. Using affinity chromatography to characterize cytokine-binding proteins, she identified soluble forms of the receptors as well as binding proteins for several cytokines, including tumor necrosis factor, interleukin (IL) 6, IL-18 and IL-32. Importantly, her work has been key in the development of monoclonal antibodies against interferons and cytokines. This Perspective discusses her contribution to the field and highlights her recent review on this topic.
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http://dx.doi.org/10.3389/fimmu.2023.1160651 | DOI Listing |
Int J Mol Sci
December 2024
Molecular Genetics, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Interleukin-18 (IL-18) serves a dual function in the immune system, acting as a "double-edged sword" cytokine. Depending on the microenvironment and timing, IL-18 can either drive harmful inflammation or restore immune homeostasis. Pathologies characterized by elevated IL-18, recently proposed to be termed IL-18opathies, highlight the therapeutic potential for IL-18 blockade.
View Article and Find Full Text PDFJ Interferon Cytokine Res
December 2023
Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel.
Front Immunol
March 2023
Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL, United States.
Front Immunol
March 2023
Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel.
Human urinary proteins are a goldmine of natural proteins a feature that simplifies their translation to biologics. Combining this goldmine together with the ligand-affinity-chromatography (LAC) purification method, proved a winning formula in their isolation. LAC specificity, efficiency, simplicity and inherent indispensability in the search for predictable and unpredictable proteins, is superior to other separation techniques.
View Article and Find Full Text PDFImmunol Res
December 2022
Department of Medicine 'B', Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
Coronavirus disease 2019 (COVID-19) is associated with immune dysregulation, severe respiratory failure, and multiple organ dysfunction caused by a cytokine storm involving high blood levels of ferritin and IL-18. Furthermore, there is a resemblance between COVID-19 and macrophage activation syndrome (MAS) characterized by high concentrations of soluble CD163 (sCD163) receptor and IL-18. High levels of ferritin, IL-18, and sCD163 receptor are associated with "hyperferritinemic syndrome", a family of diseases that appears to include COVID-19.
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