AI Article Synopsis
- Nanocarriers can enhance drug delivery for various treatments but face challenges, particularly degradation within endosomes/lysosomes after being taken up by cells.
- The review discusses advanced methods to improve delivery efficiency by facilitating escape from endosomes/lysosomes and using alternative delivery methods that bypass these pathways.
- Ultimately, the article suggests innovative design strategies for nanodrug delivery systems to overcome these cellular barriers and improve clinical outcomes in the future.
Article Abstract
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after endocytosis is the most important. This review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport mechanisms. These strategies include promoting endosomal/lysosomal escape, using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/lysosomes. On the basis of the findings of this review, we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208951 | PMC |
| http://dx.doi.org/10.34133/research.0148 | DOI Listing |
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