AI Article Synopsis
- Opportunistic fungal infections are a significant risk for cancer patients after chemotherapy due to immune suppression, and antifungal resistance is a growing concern.
- A study examined 325 cancer patients over three years, identifying fungal infections using PCR-RFLP methods and testing antifungal susceptibility based on CLSI guidelines.
- Results showed a 22.7% infection rate, predominantly by one species, with all isolates sensitive to amphotericin B, but notable resistance was found to anidulafungin, fluconazole, and itraconazole; thus, amphotericin B is recommended for treating serious infections.
Article Abstract
Objective: Opportunistic fungal infections by species arise among cancer patients due to the weakened immune system following extensive chemotherapy. Prophylaxis with antifungal agents have developed the resistance of spp. to antifungals. Accurate identification of yeasts and susceptibility patterns are main concerns that can directly effect on the treatment of patients.
Methods: Over a period of three years, 325 cancer patients suspected to infections were included in the current investigation. The clinical isolates were molecularly identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). All strains, were examined for susceptibility to the amphotericin B, itraconazole, fluconazole, and anidulafungin according to the CLSI M27 document.
Results: Seventy-four cancer patients had infections (22.7%). was the most common species (83.8%). Antifungal susceptibility results indicated that 100% of the isolates were sensitive to amphotericin B; however, 17.6%, 9.4%, and 5.4% of clinical isolates were resistant to anidulafungin, fluconazole, and itraconazole, respectively.
Conclusion: The findings of the present work shows a warning increase in resistance to echinocandins. Since all fluconazole resistance isolates were obtained from candidemia, we recommend amphotericin B as the first line therapy for this potentially fatal infection.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213519 | PMC |
| http://dx.doi.org/10.3389/fcimb.2023.1152552 | DOI Listing |
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