AI Article Synopsis
- Hepatitis B virus (HBV) infection poses a significant global health issue, with many people at risk for serious liver conditions despite available vaccines.
- Current treatments can reduce viral replication and liver damage, but they typically cannot eliminate the virus's cccDNA, which leads to long-term infection.
- Emerging strategies utilizing CRISPR/cas9 gene editing show promise in effectively inhibiting HBV replication and potentially inactivating cccDNA, with ongoing research exploring their delivery and clinical applications.
Article Abstract
Hepatitis B virus (HBV) infection remains a global health challenge. Despite the availability of effective preventive vaccines, millions of people are at risk of cirrhosis and hepatocellular carcinoma. Current drug therapies inhibit viral replication, slow the progression of liver fibrosis and reduce infectivity, but they rarely remove the covalently sealed circular DNA (cccDNA) of the virus that causes HBV persistence. Alternative treatment strategies, including those based on CRISPR/cas9 knockout virus gene, can effectively inhibit HBV replication, so it has a good prospect. During chronic infection, some virus gene knockouts based on CRISPR/cas9 may even lead to cccDNA inactivation. This paper reviews the progress of different HBV CRISPR/cas9, vectors for delivering to the liver, and the current situation of preclinical and clinical research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170306 | PMC |
| http://dx.doi.org/10.1002/iid3.866 | DOI Listing |
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