A cost-effective and competent approach has been established for the synthesis of pyrimido[4,5-]quinolines and pyrido[2,3-]pyrimidines a multicomponent reaction of 1,3 diketones (dimedone, barbituric acid, and Meldrum's acid), 6-aminouracil and aromatic aldehyde, through mechanochemical synthesis using a ball-mill. This transformation involves a one pot, catalyst-free, and solvent-free pathway to develop the desired products under mild reaction conditions.
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| http://dx.doi.org/10.1039/d3ob00626c | DOI Listing |
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