Objectives: (1) To characterize the average trajectories of frailty over time in Chinese community-dwelling older adults; (2) To assess the effects of neighborhood structural and individual characteristics on frailty progression.
Design: A nationally representative prospective cohort study.
Setting: Communities in 28 provinces, China.
Participants: 6238 respondents aged 60 and above in 447 communities from four waves of the China Health and Retirement Longitudinal Study.
Measurements: Frailty was measured using the 61-item Frailty Index (FI).
Results: The trajectory of FI was nonlinear, with an average growth rate of 0.025 that significantly slows down at the rate of 0.002 per year. Older, male, and uninsured respondents showed faster rates of growth in FI over time than younger, female, and insured counterparts. Respondents living in neighborhoods with a higher percentage of the older population and rural villages showed slower rates of growth in FI over time.
Conclusion: Expanding health insurance coverage and keeping a high clustering of the elderly in neighborhoods may be the potential strategies for population-level frailty prevention and interventions.
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http://dx.doi.org/10.1007/s12603-023-1916-1 | DOI Listing |
Gerontologist
January 2025
School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Background And Objectives: Social isolation is an increasing public health concern. Older residents in subsidized housing may be susceptible to isolation given high rates of chronic illness/disabilities, low income, and living alone. This cross-sectional study examined correlates of social isolation among over 3,000 older adults from nearly 100 subsidized housing communities across the US.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, 11461, Riyadh, Saudi Arabia.
Quantitative structure-property relationship (QSPR) modeling has emerged as a pivotal tool in the field of medicinal chemistry and drug design, offering a predictive framework for understanding the correlation between chemical structure and physicochemical properties. Topological indices are mathematical descriptors derived from the molecular graphs that capture structural features and connectivity, playing a crucial role in QSPR analysis by quantitatively relating chemical structures to their physicochemical properties and biological activities. Lung cancer is characterized by its aggressive nature and late-stage diagnosis, often limiting treatment options and significantly impacting patient survival rates.
View Article and Find Full Text PDFGerontologist
January 2025
School of Social Work, University of Washington, Seattle, Washington, USA.
Background And Objectives: The importance of social participation for older adults has been well articulated. Missing from this discourse is a critical consideration of how social participation is shaped by political, economic, and social contexts that marginalize aging and disabled bodies. We bridge this gap by applying critical gerontology and critical disability frameworks to our analysis of how access to health and social services and individual and environmental factors, are associated with engagement in valued social activities among disabled older adults.
View Article and Find Full Text PDFProc Biol Sci
January 2025
Department of Biology, Queen's University, Kingston, Ontario, Canada.
The composition of a plant's neighbourhood shapes its competitive interactions. Neighbours may be related individuals due to limited seed dispersal or clonal growth, so that the ability to recognize and respond to the presence of kin is beneficial. Here, we ask whether plants plastically adjust their floral and clonal allocation in response to their neighbour's identity.
View Article and Find Full Text PDFJ Anim Ecol
January 2025
Ecology & Evolutionary Biology, School of Biosciences, University of Sheffield, Sheffield, UK.
The evolution of sociality is one of the major evolutionary transitions in the history of life and a key step in this transition is the occurrence of kin associations. Yet, the question of what demographic processes and environmental factors generate kin-structured populations and drive kin-directed cooperation remains open. In this review, we synthesise 30 years of studies of the long-tailed tit Aegithalos caudatus, which has a kin-selected cooperative breeding system with redirected help: failed breeders may help to raise offspring of conspecifics, typically relatives, breeding nearby.
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