AI Article Synopsis
- Frailty in older adults leads to higher risks of disability and mortality, making it essential to identify factors that promote resilience against it.
- A new measure called the Frailty Resilience Score (FRS) was developed, which takes into account genetic risks, age, and sex to reliably quantify frailty resilience.
- In a study involving older adults, FRS was validated as a strong predictor of survival, showing that increases in the score correlate with significantly reduced mortality risks, and it facilitated the identification of a related proteomic profile.
Article Abstract
Frailty is characterized by increased vulnerability to disability and high risk for mortality in older adults. Identification of factors that contribute to frailty resilience is an important step in the development of effective therapies that protect against frailty. First, a reliable quantification of frailty resilience is needed. We developed a novel measure of frailty resilience, the Frailty Resilience Score (FRS), that integrates frailty genetic risk, age, and sex. Application of FRS to the LonGenity cohort (n = 467, mean age 74.4) demonstrated its validity compared to phenotypic frailty and its utility as a reliable predictor of overall survival. In a multivariable-adjusted analysis, 1-standard deviation increase in FRS predicted a 38% reduction in the hazard of mortality, independent of baseline frailty (p < .001). Additionally, FRS was used to identify a proteomic profile of frailty resilience. FRS was shown to be a reliable measure of frailty resilience that can be applied to biological studies of resilience.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10562888 | PMC |
| http://dx.doi.org/10.1093/gerona/glad138 | DOI Listing |
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