Background: We evaluated the effect of delayed hospitalization (symptom-to-door time [STD] ≥ 24 h) on 3-year clinical outcomes according to renal function in patients with non-ST-segment elevation myocardial infarction (NSTEMI) undergoing new-generation drug-eluting stent (DES) implantation.
Methods: A total of 4513 patients with NSTEMI were classified into chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m², n = 1118) and non-CKD (eGFR ≥ 60 mL/min/1.73 m², n = 3395) groups. They were further sub-classified into groups with (STD ≥ 24 h) and without (STD < 24 h) delayed hospitalization. The primary outcome was the occurrence of major adverse cardiac and cerebrovascular events (MACCE), defined as all-cause death, recurrent myocardial infarction, any repeat coronary revascularization, and stroke. The secondary outcome was stent thrombosis (ST).
Results: After multivariable-adjusted and propensity score analyses, the primary and secondary clinical outcomes were similar in patients with or without delayed hospitalization in both CKD and non-CKD groups. However, in both the STD < 24 h and STD ≥ 24 h groups, MACCE (p < 0.001 and p < 0.006, respectively) and mortality rates were significantly higher in the CKD group than in the non-CKD group. However, ST rates were similar between the CKD and non-CKD groups and between the STD < 24 h and STD ≥ 24 h groups.
Conclusions: Chronic kidney disease appears to be a much more important determinant of MACCE and mortality rates than STD in patients with NSTEMI.
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http://dx.doi.org/10.5603/CJ.a2023.0036 | DOI Listing |
BMC Oral Health
December 2024
Department of Stomatology, General Hospital of Northern Theater Command, Shenyang City, 110016, Liaoning, People's Republic of China.
Objective: Based on the critical role of implant length and placement timing in treatment success, this study aimed to compare clinical outcomes (implant failure, marginal bone loss, biological and mechanical complications) between short implants (4-8 mm) versus long implants (≥ 8 mm) with sinus floor elevation, and between delayed versus immediate placement of long implants in the posterior maxilla.
Methods: This network meta-analysis was prospectively registered in the PROSPERO database (CRD42023495027). Adhering to PRISMA-NMA guidelines, we systematically reviewed eligible studies from January 2014 to November 2024 was conducted across major databases, such as the Cochrane Library, PubMed, Embase, Scopus and Web of Science.
BMC Pediatr
December 2024
Pediatric Nursing Department, Faculty of Nursing, Benha University, Benha, Egypt.
Background: Aluminum phosphide is an excellent insecticide available as a chalky white or brown tablet. Aluminum phosphide is traded in the Egyptian market as tablets under the brand name celphos. To date, no specific antidotes for aluminum phosphide poisoning have been identified.
View Article and Find Full Text PDFInt J Emerg Med
December 2024
Pediatric Intensive Care Unit, King Salman Medical City, Madinah, Saudi Arabia.
Background: Spontaneous pneumomediastinum (SPM) and subcutaneous emphysema (SE) are rare, severe, and potentially life-threatening complications associated with asthma exacerbation. Most of these conditions are benign and self-limiting. However, the overlapping symptoms between asthma exacerbation and pneumomediastinum (PM) may delay diagnosis.
View Article and Find Full Text PDFIn Vivo
December 2024
Faculty of Medicine and Pharmacy, Doctoral School, University of Oradea, Oradea, Romania.
Background/aim: Vaccine refusal or delay remains a significant public health concern, leading to lower vaccination rates and increasing the risk of preventable diseases.
Patients And Methods: The study included 404 mothers and 413 children, assessing vaccination coverage and conducting telephone interviews with mothers who declined vaccines to understand their reasons.
Results: Children of mothers who supported vaccination were more likely to be fully immunized compared to those with hesitant mothers.
BMJ Open Qual
December 2024
Neurology Same Day Emergency Care, University College London Hospitals NHS Foundation Trust, London, UK.
There are various models for acute neurology services in the UK, with considerable variation in practice. Patients are often admitted unnecessarily for neurology review, leading to delay in diagnosis and treatment. Alternative models, such as the Neurology Same Day Emergency Care service (Neuro-SDEC) at University College London Hospital provide a pathway that can prevent admissions and streamline patient care.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!