AI Article Synopsis
- Hydrogen sulfide is a toxic but important metabolite in humans, and the study focuses on trimethylsulfonium, a compound produced from it, to assess its stability and variability in excretion among healthy individuals.
- Urinary trimethylsulfonium levels were found to be significantly lower than those of hydrogen sulfide's conventional biomarkers, thiosulfate and cystine, indicating a different metabolic profile.
- The research revealed high variability in both the intra- and inter-individual levels of trimethylsulfonium, leading to the conclusion that these variabilities should be taken into account when using it as a biomarker.
Article Abstract
Hydrogen sulfide is a toxic gas but also recognized as an endogenously produced metabolite in humans playing key roles. We previously identified trimethylsulfonium, which can be a methylation product of hydrogen sulfide but the stability in the production of trimethylsulfonium has not been investigated. In the present work, the intra- and inter-individual variability in the excretion of trimethylsulfonium over 2 months in a group of healthy volunteers was investigated. Urinary levels of trimethylsulfonium (mean: 56 nM, 95% CI: 48-68 nM) were > 100-fold lower than the conventional hydrogen sulfide biomarker thiosulfate (13 µM, 12-15 µM) and the precursor for endogenous hydrogen sulfide production cystine (47 µM, 44-50 µM). There was no correlation between urinary trimethylsulfonium and thiosulfate. Higher intra-individual variability in the excretion of trimethylsulfonium (generally 2-8 fold) than that for cystine (generally 2-3 fold) was found. Trimethylsulfonium displayed significant inter-individual variability with two concentration clusters at 117 nM (97-141) and 27 nM (22-34). In conclusion, the observed inter- and intra-individual variability must be considered when using urinary trimethylsulfonium as a biomarker.
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| http://dx.doi.org/10.1016/j.etap.2023.104162 | DOI Listing |
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