AI Article Synopsis
- White and brown adipose tissues are responsive to environmental changes and regulated by circadian rhythms, which help anticipate these changes.
- Circadian disturbances, common in our 24/7 lifestyles, increase the risk of cardiovascular and metabolic diseases.
- This review explores ways to reduce disease risk associated with these disturbances and highlights potential strategies like chronotherapy and identifying new therapeutic targets to enhance treatment effectiveness.
Article Abstract
White and brown adipose tissues are highly dynamic organs anticipating and responding to changes in the environment. The circadian timing system facilitates anticipation, and it is therefore not surprising that circadian disturbances, a prominent feature of modern 24/7 society, increase the risk for (cardio)metabolic diseases. In this mini-review, we will address mechanisms and strategies to mitigate disease risk associated with circadian disturbances. In addition, we discuss the opportunities arising from the knowledge we gained about circadian rhythms in these adipose tissues, including the application of chronotherapy, optimizing endogenous circadian rhythms to allow for more effective intervention, and the identification of novel therapeutic targets.
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| http://dx.doi.org/10.1016/j.gde.2023.102056 | DOI Listing |
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