In this study, an off-line coupling of dispersive solid-phase extraction (DSPE) and ion mobility spectrometry (IMS) was introduced to extract and determine bupropion (BUP). A magnetic nanocomposite adsorbent (FeO@CuO&GO) was fabricated by combining graphene oxide (GO) sheets with FeO and CuO through coprecipitation method. The synthesized adsorbent was characterized and analyzed using the analytical techniques. The effect of extraction parameters including desorption solvent (type and volume), pH, adsorbent amount, contact time, temperature, and the volume of analyte solution on the extraction efficiency was investigated and optimized. The operational parameters of IMS method were also investigated. Under the optimum conditions (DSPE-IMS), the proposed method provided a linear range 4.0-24.0 ng for BUP with a determination coefficient R ≥ 0.98. LOD and LOQ values were 0.7 and 2.2 ng for BUP. The repeatability of proposed method was evaluated and reported as relative standard deviation (RSD% ≤ 5.5). The developed method was applied to determine BUP in different biological samples, in which satisfactory results were obtained (93.0-98.0%).
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