We determine the product of the expansion rate and angular-diameter distance at redshift z=2.3 from the anisotropy of Lyman-α (Lyα) forest correlations measured by the Sloan Digital Sky Survey (SDSS). Our result is the most precise from large-scale structure at z>1. Using the flat Λ cold dark matter model we determine the matter density to be Ω_{m}=0.36_{-0.04}^{+0.03} from Lyα alone. This is a factor of 2 tighter than baryon acoustic oscillation results from the same data due to our use of a wide range of scales (25
Download full-text PDF
Source
http://dx.doi.org/10.1103/PhysRevLett.130.191003 DOI Listing Publication Analysis
Top Keywords
Similar Publications
A phase Ia study of a novel anti-HER2 antibody-drug conjugate GQ1001 in patients with previously treated HER2 positive advanced solid tumors.
J Transl Med
January 2025
Scientia Clinical Research and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Background: A novel anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC) GQ1001 was assessed in patients with previously treated HER2 positive advanced solid tumors in a global multi-center phase Ia dose escalation trial.
Methods: In this phase Ia trial, a modified 3 + 3 study design was adopted during dose escalation phase. Eligible patients were enrolled, and GQ1001 monotherapy was administered intravenously every 3 weeks.
Neuroplasticity in the motor cortex following the achievement of sufficient motor learning.
Neurosci Lett
January 2025
Laboratory of Neurorehabilitation, Department of Occupational Therapy, Biwako Professional University of Rehabilitation, 967 Kitasaka, Higashiomi, Shiga 527-0145, Japan.
Skilled motor training causes the cortical representation of the trained body parts to expand into regions of the motor cortex related to other body parts. However, the effect of neuroplastic changes on the neurons originally existing within the expanded area is not well understood. In this study, the extent of the neuroplastic changes after achieving sufficient motor learning and the impact of the expansion on the neurons related to movements of other body parts were investigated.
View Article and Find Full Text PDFClaudin 18.2-targeting antibody-drug conjugate CMG901 in patients with advanced gastric or gastro-oesophageal junction cancer (KYM901): a multicentre, open-label, single-arm, phase 1 trial.
Lancet Oncol
January 2025
Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China. Electronic address:
Background: CMG901 is a novel first-in-class antibody-drug conjugate with a humanised anticlaudin 18.2 antibody linked to microtubule-disrupting agent monomethyl auristatin E. We aimed to assess the antitumour activity and safety of CMG901 in patients with advanced gastric or gastro-oesophageal junction cancer and other solid tumours.
View Article and Find Full Text PDFDynamic changes and influential factors of blowouts in a desert artificial ecosystem at the southeastern margin of Tengger Desert in China.
J Environ Manage
January 2025
College of Forestry and Prataculture, Ningxia University, Yinchuan 750021, China.
The wind-blown sand protection system in the Shapotou section of the Baotou-Lanzhou Railway is a representative artificial ecosystem in a desert region. Over the past 70 years, this system has transformed mobile dunes into fixed dunes through vegetation succession, relying solely on natural rainfall without additional irrigation. However, ecosystem sustainability has been endangered by the emergence of numerous blowouts.
View Article and Find Full Text PDFA phase I study of temsirolimus in combination with metformin in patients with advanced or recurrent endometrial cancer.
Gynecol Oncol
January 2025
Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Introduction: Molecular alterations in the PI3K/AKT and Ras/Raf/MEK/ERK pathways are frequently observed in patients with endometrial cancers. However, mTOR inhibitors, such as temsirolimus, have modest clinical benefits. In addition to inducing metabolic changes in cells, metformin activates AMPK, which in turn inhibits the mTOR pathway.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!