AI Article Synopsis
- Durian fruit contains various nutrients and has been studied for its potential anticancer properties, particularly against human leukemia cells (HL-60).
- The methanolic extract from durian was found to induce DNA damage and apoptosis in HL-60 cells, confirmed by comet and DNA fragmentation assays.
- The extract causes cell cycle arrest in specific phases and promotes apoptosis by increasing pro-apoptotic proteins while decreasing anti-apoptotic proteins, supporting its anticancer mechanism.
Article Abstract
Durian ( L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer mechanism of action of the methanolic extract of the fruit of () on human leukemia (HL-60) cells. The methanolic extract of fruits exhibited its anticancer effect on HL-60 cells by inducing DNA damage and apoptosis. The DNA damage was confirmed by comet and DNA fragmentation assays. The methanolic extract of fruits has been shown to cause cell cycle arrest in HL-60 cells during the S phase and G2/M phase. Additionally, the methanolic extract caused induction of the apoptotic pathway in the HL-60 cell line. This was confirmed by increased expression in pro-apoptotic proteins, viz., Bax protein expression, and a substantial reduction ( < 0.001) in anti-apoptotic proteins, viz., Bcl-2 and Bcl-xL expressions. Therefore, this study confirms that the methanolic extract of exerts its anticancer effects on the HL-60 cell line, causing cell cycle arrest and induction of apoptosis by an intrinsic mechanism.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221080 | PMC |
| http://dx.doi.org/10.3390/nu15102417 | DOI Listing |
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