AI Article Synopsis
- Cu-catalyzed reactions using -alkoxy-2-methylanilines and alcohols produce -aminophenol derivatives effectively with IPrCuBr and AgSbF catalysts.
- The process involves a [1,3]-rearrangement where the alkoxy group moves from the nitrogen to the methyl-substituted ortho position.
- This is followed by an oxa-Michael reaction involving an intermediate known as -quinol imine.
Article Abstract
Cu-catalyzed reactions of -alkoxy-2-methylanilines and alcohols in the presence of catalytic amounts of IPrCuBr and AgSbF afforded the corresponding -aminophenol derivatives in good to high yields. These reactions proceed via a [1,3]-rearrangement, in which the alkoxy group migrates from the nitrogen atom to the methyl-substituted ortho position, followed by an oxa-Michael reaction of the resulting -quinol imine intermediate.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221852 | PMC |
| http://dx.doi.org/10.3390/molecules28104251 | DOI Listing |
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