Abdominal hysterectomy is a major surgery that is often associated with pronounced postsurgical pain. The objective of this research is to conduct a systematic review and meta-analysis of all randomized controlled trials (RCTs) and nonrandomized comparative trials (NCTs) that have surveyed the analgesic benefits and morbidity of intraoperative superior hypogastric plexus (SHP) block (intervention) compared with no SHP block (control) during abdominal hysterectomy. The Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, Web of Science, PubMed, Scopus, and Embase were searched from inception until 8 May 2022. The Cochrane Collaboration tool and Newcastle-Ottawa Scale were used to evaluate the risk of bias of RCTs and NCTs, respectively. In a random effects mode, the data were pooled as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). Five studies (four RCTs and one NCT) comprising 210 patients (SHP block = 107 and control = 103) were analyzed. The overall postsurgical pain score (n = 5 studies, MD = -1.08, 95% CI [-1.41, -0.75], < 0.001), postsurgical opioid consumption (n = 4 studies, MD = -18.90 morphine milligram equivalent, 95% CI, [-22.19, -15.61], < 0.001), and mean time to mobilization (n = 2 studies, MD = -1.33 h, 95% CI [-1.98, -0.68], < 0.001) were significantly decreased in the SHP block group contrasted with the control arm. Nevertheless, there was no significant variance between both arms regarding operation time, intraoperative blood loss, postsurgical NSAID consumption, and hospital stay. There were no major side effects or sympathetic block-related aftermaths in both groups. During abdominal hysterectomy and receiving perioperative multimodal analgesia, the administration of intraoperative SHP block is largely safe and exhibits better analgesic effects compared to cases without administration of SHP block.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220697 | PMC |
| http://dx.doi.org/10.3390/medicina59050893 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SHP-1 alleviates acute liver injury caused by Escherichia coli sepsis through negatively regulating the canonical and non-canonical NFκB signaling pathways.
Int Immunopharmacol
December 2024
Institute of Aquatic Biotechnology, College of Life Sciences, Qingdao University, Qingdao 266071, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong 266237, China. Electronic address:
SHP-1, as a protein tyrosine phosphatase, plays a key role in inflammation-related diseases. However, its function and regulatory mechanism in the imbalance of inflammatory response and acute liver injury during sepsis are still unknown. Herein, we constructed a murine model of Escherichia coli (E.
View Article and Find Full Text PDFBlocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2.
Sci China Life Sci
January 2025
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai, 200237, China.
Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy. Here, we identify a natural pentacyclic triterpenoid, Pygenic Acid A (PA), as a PD-1 signaling inhibitor. PA exerts anti-tumor activity in hPD-1 knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the PD-1 signaling transduction.
View Article and Find Full Text PDFNeoplastic ICAM-1 protects lung carcinoma from apoptosis through ligation of fibrinogen.
Cell Death Dis
August 2024
State Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Article Synopsis
- ICAM-1 is often overexpressed in non-small cell lung cancer (NSCLC), which is linked to worse patient outcomes, but the reasons for its harmful effects are not fully understood.
- Research shows that the survival of NSCLC cells relies on a signal from the interaction between fibrinogen γ chain (FGG) and ICAM-1, which activates survival pathways and prevents cell death.
- By inhibiting the interaction between ICAM-1 and FGG with a developed monoclonal antibody, researchers were able to decrease NSCLC cell survival and tumor growth in experiments, suggesting a new targeted therapy approach for NSCLC.
Impacts of Dietary Standardized Ileal Digestible Lysine to Net Energy Ratio on Lipid Metabolism in Finishing Pigs Fed High-Wheat Diets.
Animals (Basel)
June 2024
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
The present study aimed to investigate the impacts of dietary standardized ileal digestible lysine to net energy (SID Lys:NE) ratio on lipid metabolism in pigs fed high-wheat diets. Thirty-six crossbred growing barrows (65.20 ± 0.
View Article and Find Full Text PDFRegulation of hepatic lipogenesis by asymmetric arginine methylation.
Metabolism
August 2024
Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea. Electronic address:
Article Synopsis
- The study investigates how PRMT6, a protein linked to various metabolic processes, interacts with and regulates LXR alpha, which is important for hepatic lipogenesis and lipid metabolism.
- Researchers found that PRMT6 enhances the promoter activity of SREBP-1c by binding to LXR alpha and methylating it, leading to increased lipogenesis in the liver.
- The findings suggest that PRMT6 plays a significant role in controlling lipid accumulation in the liver, which could have implications for conditions like non-alcoholic fatty liver disease (NAFLD).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!