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Knowing is Half the Battle: The Factors Leading to Efficient Recruitment of Representative Samples in Schizophrenia Research.
Pharmaceut Med
January 2025
New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY, 10032, USA.
Background And Objectives: Drug development in schizophrenia is limited by the differential scaling of the active treatment and placebo arms of a study, such that, as the number of sites increases, the magnitude of placebo response disproportionately increases. The objective of this article was to identify factors conducive to efficient recruitment as a step towards trial designs allowing recruitment of more participants per site, leading to reduced variability, and potentially a smaller placebo effect.
Patients And Methods: Using the information of 554 individuals, we calculated the percentage of individuals who were screened, consented, and retained in our research, along with rationale for nonconsent.
Synthetic opioids in Poland-A cause for concern or a media distraction?
Int J Drug Policy
November 2024
Head of CINN (Reitox Focal Point Point), Poland. Electronic address:
Background: The North American continent has been battling a major health crisis defined by opioids like OxyContin and fentanyl for over two decades now. In that time, it seemed that Europe is rather resilient to a similar problem, and heroin retained its position as a the most problematic opioid. This does seem to be changing and European media, including in Poland, is starting to report on growing popularity of synthetic opioids like fentanyl.
View Article and Find Full Text PDFEngineering a wolf spider A-family toxin towards increased antimicrobial activity but low toxicity.
Toxicon
August 2024
Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Ohlebergsweg 12, 35392 Giessen, Germany; LOEWE Centre for Translational Biodiversity Genomics (LOEWE-TBG), Senckenberganlage 25, 60325 Frankfurt, Germany.
Article Synopsis
- Spider-derived peptides, known as antimicrobial peptides (AMPs), have shown potential for therapeutic use due to their insecticidal, antimicrobial, and cytolytic properties found in RTA-clade spider venoms.
- A study identified 52 AMPs in the Chinese wolf spider, particularly noting their antibacterial effects, and explored enhancing their activity through bioengineering.
- The research generated modified peptides that increased antimicrobial effectiveness while maintaining low toxicity, confirming their potential as safer therapeutic agents against infections.
Polydispersity-mediated high efficacy of an in-situ aqueous nanosuspension of PPEF.3HCl in methicillin resistant Staphylococcus aureus sepsis model.
Int J Pharm
April 2024
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai 400019, Maharashtra, India. Electronic address:
Recently, World Health Organization declared antimicrobial resistance as the third greatest threat to human health. Absence of known cross-resistance, new class, new target, and a new mode of action are few major strategies being undertaken by researches to combat multidrug resistant pathogen. PPEF.
View Article and Find Full Text PDFEvaluating drug stability and sterility in single-dose vials when accessed with a closed system transfer device.
SAGE Open Med
February 2024
ICU Medical, Lake Forest, IL, USA.
Background: Impact of drug wastage is a legitimate and persistent concern. Financial impact of drug waste is borne by the hospital network, patients, and healthcare systems. Measures to reduce drug wastage may have a positive impact throughout healthcare systems.
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