AI Article Synopsis
- Toxicokinetic study of gamma-chlordane (GCD) examined its absorption and distribution after oral doses ranging from 50 micrograms/kg to 10 mg/kg.
- Absorption rates were approximately 80% for both low and medium doses, but higher doses led to significantly elevated initial concentrations in the bloodstream.
- GCD showed rapid distribution to the liver and kidneys, but took longer to accumulate in adipose tissues, peaking at 16 hours post-administration, with concentrations in fat being about 10 times greater than in the liver.
Article Abstract
Toxicokinetic parameters of gamma-chlordane (GCD) after oral administration of various doses of radio-labelled GCD (50 micrograms/kg-10 mg/kg) were compared. Absorption of GCD were about 80% in both 0.1 and 1.0 mg/kg groups. Distributions of GCD (50 micrograms/kg and 10 mg/kg) into the liver and kidney were rapid and those into adipose tissues were relatively slow. Concentrations of GCD in adipose tissues became highest at 16 hr after administration and became about 10 times more than those in the liver. The initial concentrations of GCD calculated by two-compartment open model in high dose group (10 mg/kg) were about 200-300 times higher than those in low dose group (50 micrograms/kg). Half lives of GCD in low dose group had a tendency to be a little longer than those in high dose group. This difference seemed to be caused by the accumulation of oxychlordane in low dose group.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2131/jts.11.111 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!