AI Article Synopsis
- The use of gelatin and gelatin-blend polymers to create electrospun nanofibers has transformed the biomedical field, enhancing drug delivery and regenerative medicine scaffolds.
- Electrospun gelatin nanofibers (GNFs) are praised for their high porosity, large surface area, and biocompatibility, but face challenges such as rapid degradation and poor mechanical strength.
- To address these issues, cross-linking is necessary to improve GNFs' biological properties, making them suitable for diverse medical applications like wound healing and tissue engineering.
Article Abstract
The use of gelatin and gelatin-blend polymers as environmentally safe polymers to synthesis electrospun nanofibers, has caused a revolution in the biomedical field. The development of efficient nanofibers has played a significant role in drug delivery, and for use in advanced scaffolds in regenerative medicine. Gelatin is an exceptional biopolymer, which is highly versatile, despite variations in the processing technology. The electrospinning process is an efficient technique for the manufacture of gelatin electrospun nanofibers (GNFs), as it is simple, efficient, and cost-effective. GNFs have higher porosity with large surface area and biocompatibility, despite that there are some drawbacks. These drawbacks include rapid degradation, poor mechanical strength, and complete dissolution, which limits the use of gelatin electrospun nanofibers in this form for biomedicine. Thus, these fibers need to be cross-linked, in order to control its solubility. This modification caused an improvement in the biological properties of GNFs, which made them suitable candidates for various biomedical applications, such as wound healing, drug delivery, bone regeneration, tubular scaffolding, skin, nerve, kidney, and cardiac tissue engineering. In this review an outline of electrospinning is shown with critical summary of literature evaluated with respect to the various applications of nanofibers-derived gelatin.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205520 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e16228 | DOI Listing |
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