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Antiproliferative polycyclic polyprenylated acylphloroglucinols from . | LitMetric

Antiproliferative polycyclic polyprenylated acylphloroglucinols from .

Nat Prod Res

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.

Published: May 2024

AI Article Synopsis

Article Abstract

Bioassay-guided isolation of the stems of led to one new adamantane-type polycyclic polyprenylated acylphloroglucinols (PPAPs), (-)-garpauvinin A (), and four known analogues (). The structure and absolute configuration of was established spectroscopic techniques and ECD method. All the isolates displayed moderate antiproliferative activity against HL-60, PC-3 and Caco-2 human cancer cell lines with IC values ranging from 0.81 to 19.92 μM, and exhibited low toxicity on WPMY-1 normal human cells, showing selectivity between normal and malignant prostate cells. The biosynthetic pathways of the isolated PPAPs were proposed.

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Source
http://dx.doi.org/10.1080/14786419.2023.2217469DOI Listing

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