AI Article Synopsis
- - Metabolomics is a branch of systems biology that analyzes metabolites, helping to understand biochemical processes and physiological states, especially during aging.
- - There is a lack of established reference values for metabolites based on age, sex, and ethnicity, which are crucial for identifying deviations from normal aging and understanding the connection between aging and diseases.
- - This study created a metabolomics reference database using data from healthy individuals ages 20-100 from diverse backgrounds to explore how metabolites are associated with age, sex, and race, aiding in clinical decision-making for metabolic diseases.
Article Abstract
As one of the OMICS in systems biology, metabolomics defines the metabolome and simultaneously quantifies numerous metabolites that are final or intermediate products and effectors of upstream biological processes. Metabolomics provides accurate information that helps determine the physiological steady state and biochemical changes during the aging process. To date, reference values of metabolites across the adult lifespan, especially among ethnicity groups, are lacking. The "normal" reference values according to age, sex, and race allow the characterization of whether an individual or a group deviates metabolically from normal aging, encompass a fundamental element in any study aimed at understanding mechanisms at the interface between aging and diseases. In this study, we established a metabolomics reference database from 20-100 years of age from a biracial sample of community-dwelling healthy men and women and examined metabolite associations with age, sex, and race. Reference values from well-selected healthy individuals can contribute to clinical decision-making processes of metabolic or related diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221446 | PMC |
| http://dx.doi.org/10.3390/metabo13050591 | DOI Listing |
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