AI Article Synopsis

  • The study investigates breast cancer (BC) incidence in southern and southwestern Ethiopia, highlighting a lack of accurate epidemiological data.
  • It analyzed biopsy reports from 2015 to 2019, finding the average patient age at diagnosis to be 42.27 years, with most cases diagnosed at stage III and larger tumor sizes.
  • The results indicate that invasive ductal carcinoma is the most prevalent type of BC, and lymph node involvement is significant in relation to tumor size and surgical type.

Article Abstract

Breast cancer (BC) is the most common type of cancer in Ethiopia. The incidence of BC is also rising, but the exact figure is still poorly known. Therefore, this study was conducted to address the gap in epidemiological data on BC in southern and southwestern Ethiopia. This is a five-year (2015-2019) retrospective study. The demographic and clinicopathological data were collected from biopsy reports of different kinds of breast carcinomas in the pathology department of Jimma University Specialized Hospital and Hawassa University Specialized Referral Hospital. Histopathological grades and stages were conducted using Nottingham grading and TNM staging system, respectively. Collected data were entered and analyzed using SPSS Version-20 software. The mean age of patients at diagnosis was 42.27 (SD = 13.57) years. The pathological stage of most BC patients was stage III, and most of them had tumor sizes greater than 5 cm. Most patients had moderately differentiated tumor grade, and mastectomy was the most common type of surgery at the time of diagnosis. Invasive ductal carcinoma was the most common histological type of BC, followed by invasive lobular carcinoma. Lymph node involvement was seen in 60.5% of cases. Lymph node involvement was associated with tumor size (χ = 8.55, = 0.033) and type of surgery (χ = 39.69, < 0.001). Conclusions: This study showed that BC patients in southern and southwestern Ethiopia displayed advanced pathological stages, relatively young age at diagnosis, and predominant invasive ductal carcinoma histological patterns.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223251PMC
http://dx.doi.org/10.3390/medicines10050030DOI Listing

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