Aortic Valvular Stenosis and Heart Failure: Advances in Diagnostic, Management, and Intervention.

Heart Fail Clin

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval (IUCPQ-UL)/ Québec Heart & Lung Institute, Laval University, 2725 Chemin Sainte-Foy, Québec City, QC G1V 4G5, Canada; Department of Cardiology, Odense University Hospital, University of Southern Denmark, J. B. Winsløws Vej 4, 5000 Odense, Denmark. Electronic address:

Published: July 2023

Up to 30% of patients with aortic stenosis (AS) present with heart failure (HF) symptoms with either reduced or preserved left ventricular ejection fraction. Many of these patients present with a low-flow state, reduced aortic-valve-area (≤1.0 cm) with low aortic-mean-gradient and aortic-peak-velocity (<40 mm Hg and <4.0 m/s). Thus, determination of true severity is essential for correct management, and multi-imaging evaluation must be performed. Medical treatment of HF is imperative and should be optimized concurrently with the determination of AS-severity. Finally, AS should be treated according to guidelines, keeping in mind that HF and low-flow increase interventions risks.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hfc.2023.02.005DOI Listing

Publication Analysis

Top Keywords

stenosis heart
8
heart failure
8
aortic valvular
4
valvular stenosis
4
failure advances
4
advances diagnostic
4
diagnostic management
4
management intervention
4
intervention 30%
4
30% patients
4

Similar Publications

Left ventricular outflow tract (LVOT) obstruction is mostly caused by hypertrophic obstructive cardiomyopathy and subaortic stenosis. Rarely, malignancy can lead to dynamic LVOT obstruction and has only been sporadically documented. We present the first case of dynamic and/or nearly fixed LVOT obstruction caused by a cardiac myxoid spindle cell sarcoma.

View Article and Find Full Text PDF

Transcatheter Aortic Valve Replacement in Patients With Interventricular Membranous Septal Aneurysms.

JACC Case Rep

January 2025

Interventional Cardiology Section, Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

Aneurysms of the interventricular membranous septum are a rare anatomical feature that can be detected incidentally on computed tomography or echocardiography. Such aneurysms can pose challenges in the treatment of patients with aortic valve stenosis. A case series of 2 patients with membranous septal aneurysms treated successfully with current-generation balloon-expandable and self-expanding transcatheter heart valves is presented here.

View Article and Find Full Text PDF

A 77-year-old man with multiple comorbidities presented with cough, dyspnea and nonspecific malaise. Chest computed tomography revealed a mass in the right lower lobe of the lung, along with an associated hypodense lesion in the left atrium. Echocardiography showed a mobile mass in the left atrium, initially suspected to be a thrombus.

View Article and Find Full Text PDF

Aim: Left atrial (LA) strain is emerging as a valuable metric for evaluating cardiac function, particularly under pathological conditions such as pressure overload. This preclinical study investigates the predictive utility of LA strain on cardiac function in a murine model subjected to pressure overload, mimicking pathologies such as hypertension and aortic stenosis.

Methods: High-resolution ultrasound was performed in a cohort of mice (n = 16) to evaluate left atrial and left ventricular function at baseline and 2 and 4 weeks after transverse aortic constriction (TAC).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!