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Evaluation of Safety and Efficacy of a Single Lorecivivint Injection in Patients with Knee Osteoarthritis: A Multicenter, Observational Extension Trial.
Rheumatol Ther
January 2025
Biosplice Therapeutics, Inc., 9360 Towne Centre Dr, San Diego, CA, 92121, USA.
Introduction: Lorecivivint (LOR), a CDC-like kinase/dual-specificity tyrosine kinase (CLK/DYRK) inhibitor thought to modulate inflammatory and Wnt pathways, is being developed as a potential intra-articular knee osteoarthritis (OA) treatment. The objective of this trial was to evaluate long-term safety of LOR within an observational extension of two phase 2 trials.
Methods: This 60-month, observational extension study (NCT02951026) of a 12-month phase 2a trial (NCT02536833) and 6-month phase 2b trial (NCT03122860) was administratively closed after 36 months as data inferences became limited.
Flat Aesthetic Mastectomy Closure with the Angel Wing Technique to Address Lateral Adiposity: Technique and Outcome Analysis.
Breast J
January 2025
Division of Breast Surgical Oncology, Department of Surgery, University of Arkansas for Medical Sciences and the Winthrop P. Rockefeller Cancer Institute, Little Rock, AR, USA.
Article Synopsis
- The introduction discusses challenges in achieving flat closure during oncologic mastectomy in obese patients and introduces the angel wing (AW) technique as a solution.
- A retrospective study at an academic center evaluated the safety of the AW technique by analyzing postoperative arm lymphedema (AL) and decreased range of motion (dROM) in patients who underwent mastectomy with and without this technique.
- Results showed no significant difference in the incidence of AL or dROM between the AW and non-AW groups, suggesting that the AW technique is a safe option for achieving effective surgical outcomes in obese patients postmastectomy.
Frequency and categorization of presleep fantasies.
Sci Rep
December 2024
Department of Neurology, Medical School, University of Pécs, Pécs, Hungary.
The content of presleep thoughts have been assumed to influence sleep quality for a long time, e.g., insomnia has repeatedly been discussed to be associated with anxious thoughts before falling asleep.
View Article and Find Full Text PDFChoosing the right frame: how context preferences facilitate subsequent decisions.
Sci Rep
December 2024
Division of Computational & Data Sciences, Washington University in St. Louis, St. Louis, MO, USA.
Context shapes how we perceive choices and, therefore, how we decide between them. For instance, a large body of literature on the "framing effect" demonstrates that people become more risk-seeking when choices are framed in terms of losses. Despite this research, it remains unknown how people make choices between contexts and how these choices affect subsequent decision making.
View Article and Find Full Text PDFAssociation Does Not Mean Causation, When Observational Data Were Misinterpreted as Causal: The Observational Interpretation Fallacy.
J Eval Clin Pract
February 2025
Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Background: The differentiation between association and causation is a significant challenge in medical research, often further complicated by cognitive biases that erroneously interpret coincidental observational data as indicative of causality. Such misinterpretations can lead to misguided clinical guidelines and healthcare practice, potentially endangering patient safety and leading to inefficient use of resources.
Methods: We conducted an extensive search of PubMed, Cochrane, and Embase databases up to March 2024, identifying circumstances where associations from observational studies were incorrectly deemed causal.
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