AI Article Synopsis
- Vertebrate photoreceptor cells detect light in varying conditions through phototransduction, heavily influenced by cGMP and Ca as secondary messengers.
- Feedback mechanisms involving proteins like GCAPs and recoverins help these cells adjust and maintain sensitivity after exposure to light.
- The review discusses the differences among various Ca-sensor proteins in terms of their signaling roles, conformational changes, and interactions, highlighting how they work together to optimize responsiveness to different light environments.
Article Abstract
Vertebrate photoreceptor cells are exquisite light detectors operating under very dim and bright illumination mediated by phototransduction, which is under control of the two secondary messengers cGMP and Ca. Feedback mechanisms enable photoreceptor cells to regain their responsiveness after light stimulation and involve neuronal Ca-sensor proteins, named GCAPs (guanylate cyclase-activating proteins) and recoverins. This review compares the diversity in Ca-related signaling mediated by GCAP and recoverin variants that exhibit differences in Ca-sensing, protein conformational changes, myristoyl switch mechanisms, diversity in divalent cation binding and dimer formation. In summary, both subclasses of neuronal Ca-sensor proteins contribute to a complex signaling network in rod and cone cells, which is perfectly suited to match the requirements for sensitive cell responses and maintaining this responsiveness in the presence of different background light intensities.
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| http://dx.doi.org/10.1016/j.bbamcr.2023.119491 | DOI Listing |
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