AI Article Synopsis
- Three Schiff-based fluorescent probes with unique features were created to detect specific metal ions, including a tri-responsive probe called SN-Cl.
- SN-Cl can selectively identify Pb, Ag, and Fe in various solvents or with masking agents, achieving significant fluorescence enhancement without interference from other ions, while the other probes only detect Pb in one specific buffer solution.
- The LOD for SN-Cl is very low, making it effective for real water sample detection and as an imaging agent for Fe in HeLa cells, showcasing its potential as a versatile tool for monitoring multiple targets in scientific applications.
Article Abstract
In this work, three Schiff-based fluorescent probes with aggregation-induced emission (AIE) and excited intramolecular proton transfer (ESIPT) characters were synthesized by grafting 2-aminobenzothiazole group onto 4-substituted salicylaldehydes. More important, a rare tri-responsive fluorescent probe (SN-Cl) was developed by purposeful variation of substituents in the molecule. It could selectively identify Pb, Ag and Fe in different solvent systems or with the help of masking agent and show complete fluorescence enhancement without interference of other ions. Meanwhile, the other two probes (SN-ON and SN-N) could only recognize Pb in DMSO/Tris-HCl buffer (3: 7, v/v, pH = 7.4). According to Job's plot, density functional theory (DFT) calculations and NMR analysis, coordination between SN-Cl and Pb/Ag/Fe was determined. The LOD values for three ions were as low as 0.059 μM, 0.012 μM and 8.92 μM, respectively. Ideally, SN-Cl showed satisfactory performance in real water samples detection and test paper experiments for three ions. Also, SN-Cl could be used as an excellent imaging agent for Fe in HeLa cells. Therefore, SN-Cl has the ability to be a "single fluorescent probe for three targets".
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| http://dx.doi.org/10.1016/j.saa.2023.122904 | DOI Listing |
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