World Health Organization (WHO) proclaimed the Corona virus (COVID-19) as a pandemic, since it contaminated billions of individuals and killed lakhs. The spread along with the severity of the disease plays a key role in early detection and classification to reduce the rapid spread as the variants are changing. COVID-19 could be categorized as a pneumonia infection. Bacterial pneumonia, fungal pneumonia, viral pneumonia, etc., are the classifications of several forms of pneumonia, which are subcategorized into more than 20 forms and COVID-19 will come under viral pneumonia. The wrong prediction of any of these can mislead humans into improper treatment, which leads to a matter of life. From the radiograph that is X-ray images, diagnosis of all these forms can be possible. For detecting these disease classes, the proposed method will employ a deep learning (DL) technique. Early detection of the COVID-19 is possible with this model; hence, the spread of the disease is minimized by isolating the patients. For execution, a graphical user interface (GUI) provides more flexibility. The proposed model, which is a GUI approach, is trained with 21 types of pneumonia radiographs by a convolutional neural network (CNN) trained on Image Net and adjusts them to act as feature extractors for the Radiograph images. Next, the CNNs are combined with united AI strategies. For the classification of COVID-19 detection, several approaches are proposed in which those approaches are concerned with COVID-19, pneumonia, and healthy patients only. In classifying more than 20 types of pneumonia infections, the proposed model attained an accuracy of 92%. Likewise, COVID-19 images are effectively distinguished from the other pneumonia images of radiographs.
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http://dx.doi.org/10.1007/s00354-023-00212-7 | DOI Listing |
J Epidemiol Glob Health
January 2025
Center of Clinical Laboratory, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, No.201-209 Hubinnan Road, Xiamen, 361004, China.
Background: During the COVID-19 outbreak in December 2022 in China, some laboratory workers in SARS-CoV-2 nucleic acid testing (NAT) laboratories remained uninfected.
Objectives: To evaluate if the incidence of SARS-CoV-2 infection was reduced in laboratory workers who performed SARS-CoV-2 NAT, and whether this reduction resulted from the healthy worker effect.
Methods: This retrospective cohort study included 423 laboratory workers from 14 SARS-CoV-2 NAT laboratories in Xiamen, China.
Microbiol Resour Announc
January 2025
Molecular Biology and Bioinformatics Laboratory, Department of Gynecology, Obstetrics and Reproductive Health, Bangabandhu Sheikh Mujibur Rahman Agricultural University (BSMRAU), Gazipur, Bangladesh.
Milk from cows with mastitis is a primary source of bacteria harboring antibiotic resistance genes (ARGs), including . We present the genome sequence of strain MBBL2 isolated from mastitic cow milk, which contains numerous ARGs and virulence-associated genes potentially pathogenic to humans.
View Article and Find Full Text PDFmSphere
January 2025
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Unlabelled: During infection, bacterial pathogens rely on secreted virulence factors to manipulate the host cell. However, in gram-positive bacteria, the molecular mechanisms underlying the folding and activity of these virulence factors after membrane translocation are not clear. Here, we solved the protein structures of two secreted parvulin and two secreted cyclophilin-like peptidyl-prolyl isomerase (PPIase) ATP-independent chaperones found in gram-positive streptococcal species.
View Article and Find Full Text PDFAntimicrob Agents Chemother
January 2025
Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, China.
Eravacycline is a broad-spectrum fluorocycline currently approved for complicated intra-abdominal infections (cIAIs). In lung-infection models, it is effective against methicillin-resistant (MRSA) and tetracycline-resistant MRSA. As such, we aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model to evaluate eravacycline's pulmonary distribution and kinetics.
View Article and Find Full Text PDFmBio
January 2025
Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Unlabelled: Post-acute sequelae of COVID-19 involves several organs, but its basis remains poorly understood. Some infected cells in mice survive the acute infection and persist for extended periods in the respiratory tract but not in other tissues. Here, we describe two experimental models of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection to assess the effect of viral virulence on previously infected cells.
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