Prevalence and antimicrobial susceptibility of spp. in a tertiary care hospital in Peshawar: a cross-sectional study.

Unlabelled: spp. have been a primary cause of nosocomial infections worldwide, causing significant morbidity and mortality, especially in Pakistan. The purpose of this study was to investigate the trend of antimicrobial resistance over a 5-year period in a tertiary care hospital in Pakistan.

Methods: A retrospective cross-sectional study regarding the occurrence and antimicrobial resistance of spp. recovered from clinical specimens that were referred to the Pathology Laboratory of Northwest General Hospital, Peshawar. The data from 2014 to 2019 was recorded and analyzed by the laboratory. Sociodemographic characteristics and laboratory record data was analyzed using SPSS, version 25. A chi-square test was applied to see the significance.

Results: Of 59 483 clinical samples, strains were detected in 114 of them. The majority of the clinical samples were from blood (89.5%) followed by sputum (7.9%), wound swab (1.8%), and bone marrow (0.9%). has been found in 52 men (67.53%) and 28 women (75.67%), with an overall risk of 0.669 times. In 76 men (98.70%), sensitivity for ertapenem (99.1), colistin (96.49), and tigecycline (78.9%) were also observed which indicated the potential viability of these drugs to treat multidrug-resistant (MDR) infections. The male-to-female risk ratio was 0.98 for colistin and 0.71 for amikacin.

Conclusion: Increased frequency of MDR supports the need for continuous surveillance to determine the prevalence and evolution of MDR spp. in Pakistan. Colistin, tigecyclines, and ertapenem remain the possible line of drugs to treat MDR .